Guna Profem® Plus is an advanced nutraceutical developed to support the physical and emotional wellbeing of women during perimenopause and menopause. It combines carefully selected botanical extracts, targeted probiotics, prebiotic fibre (FOS), zinc, and naturally occurring plant isoflavones to provide comprehensive support for hormonal balance, mood, sleep, intestinal health, and healthy ageing.

Unlike products that focus on a single symptom, Profem® Plus is designed to support multiple physiological systems affected by declining oestrogen levels, including the neuroendocrine, gastrointestinal, skeletal, cardiovascular, and genitourinary systems. The formulation includes six gastro-protected probiotic strains to help maintain a healthy gut microbiome, recognising the important role the intestinal flora plays in hormone metabolism and overall wellbeing.

Primary Physiological Actions

Profem® Plus is traditionally used to support:

• Healthy hormonal balance during menopause.
• Relief of hot flushes and night sweats.
• Emotional wellbeing and mood regulation.
• Healthy sleep patterns.
• Intestinal microbiome balance.
• Bone health.
• Cardiovascular health.
• Healthy skin elasticity and hydration.
• Genitourinary health.
• Overall vitality during the menopausal transition.

Traditional Indications

Within integrative and biological medicine, Guna Profem® Plus is traditionally considered where support is desired for:

• Perimenopause.
• Menopause.
• Hot flushes.
• Night sweats.
• Mood changes.
• Irritability.
• Nervousness.
• Sleep disturbances.
• Vaginal dryness.
• Reduced skin elasticity.
• Intestinal dysbiosis.
• Weight gain associated with menopause.
• Water retention.
• Osteoporosis prevention programmes.
• General healthy ageing in women.

Commonly Used by Practitioners For

• Menopausal symptom support.
• Hormonal balance.
• Emotional wellbeing.
• Sleep optimisation.
• Intestinal health.
• Bone support.
• Healthy ageing.
• Skin health.
• Weight management.
• Comprehensive female wellness programmes.

Key Ingredients

Profem® Plus contains a synergistic combination of:

• Soy Isoflavones – standardised to support hormonal balance.
• Red Clover Extract – naturally rich in isoflavones for menopausal support.
• Kudzu (Pueraria lobata) – supports neurovegetative balance and menopausal comfort.
• Vitex agnus-castus (Chaste Tree) – supports female hormonal regulation.
• Griffonia simplicifolia – a natural source of 5-HTP to support mood and sleep.
• Green Tea Extract – rich in polyphenols providing antioxidant support.
• Fructo-oligosaccharides (FOS) – prebiotic fibre supporting beneficial gut bacteria.
• Six Microencapsulated Probiotic Strains:
  • Bifidobacterium lactis
  • Lactobacillus acidophilus
  • Lactobacillus paracasei
  • Lactobacillus rhamnosus
  • Lactobacillus plantarum
  • Lactobacillus salivarius
• Bifidobacterium lactis Bb1 – naturally rich in zinc.
• Zinc – contributes to the normal function of the immune system.

Common Complementary Remedies

Depending on the clinical presentation, Profem® Plus is commonly combined with:

• Guna Beta-Estr-ad-iol – female hormonal regulation.
• Guna Progesterone – hormonal balance.
• FSH D6 – ovarian support.
• LH D6 – reproductive hormone regulation.
• Guna Mela-tonin – sleep and circadian rhythm support.
• Coenzyme Compositum – cellular metabolism and vitality.
• Ubichinon Compositum – mitochondrial energy production.
• Guna Senectus F – healthy female ageing.
• GUNABASIC – bone health support where indicated.
• GUNAMINO Formula – body composition and muscle support during menopause.

Dosage

Take 1 sachet daily, preferably 30 minutes before a meal. For women wishing to support restful sleep, it is generally recommended to take the sachet 30 minutes before the evening meal.

Dissolve the contents of one sachet in half a glass of room-temperature water, stir thoroughly, and drink immediately.

For best results, GUNA recommends using one sachet daily for approximately 3 months.