Part 1 of a two-part Deep GUNA Research series on how GUNA's biotherapy remedies — cytokines, hormones and neuropeptides, and growth factors — are actually dosed and selected in practice.
This article is written for a practitioner audience and draws directly on GUNA's own published dosing-guide reference material. It is educational in nature and does not replace clinical judgement or personalised medical advice.
Our earlier GUNA Method and Cytokines articles covered the theory behind GUNA's low-dose biotherapy remedies and the underlying immunology. This article covers something more practical: how GUNA's own reference material recommends these remedies actually be dosed and selected — across all three of GUNA's individual-remedy biotherapy classes: cytokines, hormones and neuropeptides, and growth factors.
Two Prescribing Strategies
GUNA's dosing guide sets out two parallel decisional approaches, used across all three biotherapy classes:
- The aetiological decisional process. This is lab- or profile-led: if a condition reflects a down-regulation (deficiency) of a given cytokine, hormone or growth factor, the same substance is used to replace it, at physiological low dose. If the condition instead reflects an up-regulation (excess), the strategy shifts to the substance's physiological antagonist — the "opposing" cytokine or hormone, consistent with the body's own negative-feedback physiology — rather than simply escalating the homeopathic dilution of the same remedy.
- The symptomatological decisional process. This is simpler and more accessible without lab confirmation: the remedy is chosen to suit the patient's presenting symptoms, using a symptom-to-remedy correlation reference. Part 2 of this series is a full A–Z version of that correlation index.
One point GUNA's material is explicit about: because these are biological signalling molecules acting through genuine receptor mechanisms — not classical homeopathic remedies — their efficacy is tied to physiological concentration, not to potency escalation in the classical homeopathic sense. That's why the antagonist strategy exists at all: to modulate an excess, GUNA reaches for the opposing physiological signal rather than a higher dilution of the same one.
Dosing Mechanics Common to All Three Classes
The practical mechanics of dosing are the same across cytokines, hormones/neuropeptides, and growth factors:
- Standard posology: 20 drops, twice a day, taken sublingually.
- Chronic disease: treatment cycles of a minimum 2 months, repeatable, preferably separated by a 15-day suspension.
- Acute disease: therapy continued until symptom remission.
- Massive dose option (for acute presentations): 10 drops every 20 minutes, for a maximum of 2 hours.
Dilution Conventions by Class
The dilution GUNA uses reflects the physiological concentration range of each molecule class, not an arbitrary homeopathic scale:
- Cytokines and growth factors are marketed at 4CH (picogram/ml range).
- Hormones and neuropeptides are marketed mostly at 6DH (nanogram/ml range) — with three specific exceptions dosed at 4CH (picogram/ml) instead: Beta-Endorphin, Melatonin and Somatostatin.
- Maintenance dilutions of 15CH/30CH (for 4CH-range remedies) or 30DH (for 6DH-range remedies) are also available, used at times to stabilise results achieved with the primary dilution.
Cytokines: The Aetiological Pairing Table
We've covered the individual biology of each of these cytokines in detail in our Cytokines two-part series — this table is GUNA's own dosing-guide summary of which cytokine to reach for, and which antagonist to use against an excess:
GUNA's booklet lists separate Anti IL-1 alpha and Anti IL-1 beta entries; we carry a single Anti IL-1 remedy that covers this pairing.
Hormones and Neuropeptides: The Aetiological Pairing Table
The hormone and neuropeptide line follows the same replace-the-deficiency / use-the-antagonist-for-excess logic, now applied to the endocrine and neuro-endocrine axis rather than the immune system:
Dopamine, Oxytocin and Parathyroid Hormone are named in GUNA's dosing-guide reference above for completeness, but aren't currently part of our individual hormone range — the other remedies in this table are.
For GH, GUNA's own material lists IGF-1 as the strengthening remedy rather than a direct GH preparation, reflecting IGF-1's role as GH's downstream physiological mediator.
Growth Factors: Why There's No "Modulation" Pairing
The growth factor line breaks from the cytokine and hormone pattern in one specific way: GUNA's dosing guide describes growth factors as prescribed only aetiologically, in the deficiency-replacement direction — there's no antagonist/"opposing growth factor" pairing offered, and no excess-modulation strategy described. In practice, this means growth factor prescribing under the aetiological model is simpler than the other two classes: if a condition reflects reduced growth-factor signalling, the same growth factor is used at low dose; there's no equivalent "excess" branch to plan around.
The growth factor range itself — BDNF, CNTF, EGF, FGF, G1 (GD3 Ganglioside), GCSF, IGF-1, NGF, NT3, NT4, PDGF and TGF-β1 — is prescribed symptomatologically far more often than the cytokine or hormone lines, precisely because there's no lab-driven "excess" branch to check against. Part 2 of this series sets out the full symptom-led correlation for all three classes, including growth factors, in one A–Z reference.
What Follows
The next article in this series is the complete symptom-to-remedy correlations index from GUNA's dosing guide — a full A–Z quick reference cross-linking presenting symptoms and conditions back to the specific cytokine, hormone, neuropeptide or growth factor GUNA associates with them.
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Related reading
- The Complete GUNA Symptom-to-Remedy Correlations Index
- The GUNA Method Therapeutic Triangle: PNEI Rebalance, Drainage and Symptom Treatment
- Cytokines: How the Immune System's Messengers Work
Source: GUNA, biotherapy dosing guide (Cytokines / Hormones & Neuropeptides / Growth Factors sections).
Tags: Deep Guna Research, Guna Articles, Biotherapy Dosing