Part 2 of our Deep GUNA Research series on Collagen Medical Devices, for practitioners.
This article is written for a practitioner audience and draws directly on GUNA's own published reference material on Collagen Medical Devices. It is educational in nature and does not replace clinical judgement or personalised medical advice. All 13 devices below are medical devices intended for administration by a qualified medical practitioner only.
This article is a complete reference to all 13 products in GUNA's Collagen Medical Devices range, covering composition, intended use, standard therapeutic protocol, and the combinations GUNA recommends for specific clinical presentations. For the underlying theory and mechanism, see Part 1 of this series. For the anatomical injection technique per body region, see Part 3.
Products are grouped below as GUNA groups them: seven devices for specific anatomical regions, then six devices organised by tissue type. Within each entry, "connective/aging support" combinations refer to pairing with MD-MATRIX and MD-TISSUE — the two devices GUNA positions as general extracellular-matrix and connective-tissue support, usable alongside any of the region-specific devices.
Anatomical Region Devices
MD-HIP
Collagen + Calcium Phosphate
Intended use: improve movement of the hip joint; support periarticular and lumbosacral muscle tissue; soothe local pain and pain caused by joint movement or bad posture.
Directions: one treatment weekly for 10 consecutive weeks, delivered as a periarticular injection.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: hip joint osteoarthritis; hip joint capsule inflammation; hip joint inflammation with rheumatoid arthritis (+MD-POLY); hip joint pain of muscle origin (+MD-MUSCLE); hip joint pain of nerve origin, including "burning hip" (+MD-NEURAL); hip joint pain due to prolonged bed rest.
MD-KNEE
Collagen + Arnica
Intended use: improve knee mobility; help muscle stretching; soothe pain while moving the legs and knee.
Directions: one treatment weekly for 10 consecutive weeks, as a periarticular or, where indicated, intra-articular injection.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: post-traumatic or post-surgery acute and chronic arthrosynovitis; knee arthrosynovitis secondary to autoimmune disease (+MD-POLY); knee localisation of rheumatoid arthritis (+MD-POLY); patello-femoral arthrosis (+MD-POLY); meniscal lesions (+MD-MUSCLE); traumatic lesions of the cruciate or collateral ligaments (+MD-MUSCLE, +MD-POLY); joint preparation ahead of meniscectomy or post-surgical arthritis (+MD-MUSCLE and MD-NEURAL); maintenance therapy after knee surgery.
MD-LUMBAR
Collagen + Hamamelis
Intended use: help lumbar mobility; help muscle stretching of the lumbosacral spine; support lumbar muscle tissue; soothe local pain, whether at rest or from movement and bad posture.
Directions: acute presentations — 2 treatments weekly for the first 2 weeks, then 1 weekly until improvement (average 8–10 sessions). Chronic presentations — 1 treatment weekly for 1 month until improvement, then 1 every 45–50 days.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: lumbar pain secondary to cartilage-degenerative lumbar spine disorders (lumbar or lumbosacral arthrosis); lumbar vertebral osteophytosis; low back pain secondary to musculo-tendinous trigger points (+MD-MUSCLE); postural low-back ache (+MD-MUSCLE, +MD-TISSUE); lumbar or lumbosacral mechanical imbalance (+MD-NEURAL); sacro-iliac syndrome (+MD-MATRIX); spinal lumbar or lumbosacral nerve root pain (+MD-NEURAL and MD-ISCHIAL).
MD-NECK
Collagen + Silica
Intended use: improve movement of the cervical spine; help cervical muscle stretching; support cervical muscle tissue, including in bad posture disorders; soothe pain associated with cervical movement.
Directions: 1–2 treatments weekly for 10 consecutive weeks, as a periarticular injection.
Note: patients on anticoagulant therapy, or with recognised vessel fragility, should be monitored carefully.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY (particularly for facet joint syndrome) or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: neck pain from cervical cartilage-degenerative disorders (cervical osteoarthritis, +MD-POLY); neck pain from cervical muscular trigger points (+MD-MUSCLE); stiff neck syndrome (+MD-MUSCLE); whiplash (+MD-NEURAL and MD-MUSCLE); postural neck ache (+MD-NEURAL and MD-MUSCLE); mechanical imbalance / facet joint syndrome (+MD-NEURAL); cervical spinal ligament syndrome (+MD-MATRIX and MD-NEURAL); cervical spinal nerve root pain (+MD-NEURAL).
MD-SHOULDER
Collagen + Iris
Intended use: improve shoulder and arm joint mobility; help muscle stretching; support muscle tissue; soothe local pain and pain caused by movement.
Directions: 1–2 treatments weekly for 10 consecutive weeks, as a periarticular or intra-articular injection.
Combinations: for acute pain, pair with MD-NECK, MD-MUSCLE, MD-NEURAL, MD-POLY or MD-TISSUE.
Clinical presentations: shoulder-arm polyarthritis (+MD-POLY); rotator cuff syndrome (+MD-MUSCLE); shoulder-arm syndrome (+MD-NEURAL); frozen shoulder (+MD-MUSCLE); shoulder pain from dislocation, alongside therapeutic rest (+MD-NEURAL); epicondylitis, alongside therapeutic rest (+MD-POLY).
MD-SMALL JOINTS
Collagen + Viola
Intended use: improve movement of the small joints of the hand, foot and ankle; help muscle stretching and support; soothe local pain and pain from joint movement.
Directions: one treatment weekly for 10 consecutive weeks, as a periarticular or intra-articular injection.
Combinations: for acute pain, pair with MD-NEURAL, MD-MUSCLE or MD-POLY; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: osteoarthritis of the fingers; rhizoarthrosis of the thumb (Forestier disease); arthrosis pain from hammer toe; carpal-tunnel syndrome (+MD-NEURAL); De Quervain disease (+MD-NEURAL); metatarsal pain (+MD-NEURAL); metatarsal pain with Morton's neuroma (+MD-NEURAL); rheumatoid arthritis of the hand or foot (+MD-NEURAL or +MD-POLY); hand or foot tendon pain from prolonged immobilisation (+MD-MATRIX and MD-TISSUE).
MD-THORACIC
Collagen + Cimicifuga
Intended use: improve movement of the thoracic spine; help muscle stretching; support muscle tissue in bad posture disorders; soothe local pain from movement and bad posture.
Directions: 2 treatments weekly for the first 2 weeks, then 1 weekly until improvement (average 8–10 sessions). Chronic presentations — 1 treatment weekly for 1 month until improvement, then monthly.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: thoracic pain from cartilage-degenerative disorders (thoracic osteoarthritis, +MD-POLY); thoracic pain from thoracic spine osteophytosis (+MD-NEURAL); thoracic pain from scoliosis (+MD-MUSCLE and MD-NEURAL); thoracic pain from long-muscle trigger points (+MD-MUSCLE); pain secondary to spinal osteoporosis (+MD-NEURAL and MD-MUSCLE); mechanical imbalance / costo-vertebral facet joint syndrome (+MD-NEURAL); thoracic spinal ligament syndrome (+MD-NEURAL or +MD-MATRIX); thoracic spinal nerve root pain (+MD-NEURAL).
Tissue-Type Devices
MD-ISCHIAL
Collagen + Rhododendron
Intended use: improve leg mobility; help leg muscle stretching and support; soothe leg pain, particularly on starting to move again after a period of prolonged inactivity.
Directions: one treatment weekly for 10 consecutive weeks, as a periarticular injection near the sacroiliac joint.
Combinations: for acute pain, pair with MD-NEURAL, MD-POLY or MD-MUSCLE; for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: sciatic pain; lumbar-sciatic pain (+MD-LUMBAR and MD-NEURAL); nerve pain in the lower lumbar spine (+MD-NEURAL); leg nerve pain following surgical treatment of disc herniation at L4–L5 or L5–S1 (+MD-NEURAL); Morton's neuroma (+MD-NEURAL, +MD-TISSUE).
MD-MATRIX
Collagen + Citric Acid + Nicotinamide (Vitamin PP)
Intended use: help movement by limiting the physiological degeneration of joints and tissues, and by counterbalancing the effects of ageing, bad posture, chronic disease, injury and pollutants. Strengthens the supportive tissue of joints, skin and subcutaneous tissue via a barrier effect, lubricating action, and mechanical support during other pharmacological treatment. Also used for firming the subcutaneous and microvascular connective tissue affected by localised adiposity and cellulite, particularly at the root of the thigh and inner knee.
Directions: 2 treatments weekly for the first 2 weeks, then 1 weekly until improvement (average 8–10 sessions); may continue at 1 treatment every other week for up to 10 weeks in total. Chronic presentations — 1 treatment weekly for 1 month until improvement, then monthly. Administered as an intradermal or subcutaneous microinjection (0.2–0.3ml into the affected tissue) or as a periarticular injection.
Combinations: for localised adiposity or subcutaneous firming, GUNA recommends pairing with MD-TISSUE — typically 2 vials of MD-MATRIX to 1 vial of MD-TISSUE per treatment. Also indicated for patients who need general collagen supplementation or a topical anti-ageing treatment.
MD-MUSCLE
Collagen + Hypericum
Intended use: enhance muscle relaxation and function; support muscle tissue in bad posture disorders; improve joint movement; soothe local pain and pain from movement or bad posture.
Directions: 1–2 treatments weekly for 10 consecutive weeks, as an intramuscular or periarticular injection.
Note: no known history of hypersensitivity to MD-MUSCLE; where hypersensitivity to any ingredient is suspected, a spot test injection into one arm, monitored for one hour, is recommended before full treatment.
Combinations: for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: pain management (acute, subacute or chronic, +MD-NEURAL); referred somatic pain area management (+MD-NEURAL); mechanical imbalance / facet joint syndrome (+MD-NECK and MD-NEURAL); trigger point management (+MD-NEURAL); fibromyalgia syndrome (+MD-NEURAL); dermatomyositis.
MD-NEURAL
Collagen + Colocynthis
Intended use: strengthen the collagen structure of the perineurium and soothe local neural pain; help joint movement, particularly in bad posture disorders.
Directions: 1–2 treatments weekly for 10 consecutive weeks, as a periarticular or intra-articular injection.
Note: no known history of hypersensitivity to MD-NEURAL; where hypersensitivity is suspected, a spot test injection, monitored for one hour, is recommended.
Combinations: for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: MD-NEURAL is GUNA's primary companion device for nerve-origin pain across the range — brachial pain (+MD-NECK); brachial nerve pain from cervical entrapment (+MD-NECK); persistent intercostal neuralgia (+MD-THORACIC); postherpetic neuralgia (+MD-NECK or MD-THORACIC/MD-LUMBAR, depending on site); atypical facial neuritis (+MD-NECK); trigeminal neuralgia (+MD-NECK); temporomandibular joint pain (+MD-NECK); cervical, thoracic, lumbar and sacrolumbar nerve root pain (respectively +MD-NECK, +MD-THORACIC, +MD-LUMBAR, +MD-ISCHIAL).
MD-POLY
Collagen + Drosera
Intended use: improve movement of the joints; help muscle stretching; support muscle tissue in bad posture disorders; soothe local pain and pain from joint movement or bad posture.
Directions: 1–2 treatments weekly for 10 consecutive weeks, as a periarticular or intra-articular injection.
Combinations: for connective-tissue and ageing support, pair with MD-MATRIX and MD-TISSUE.
Clinical presentations: small joint rheumatoid arthritis of the hand or foot (+MD-SMALL JOINTS); non-specific diffuse pain (+MD-NECK and MD-NEURAL, or +MD-SMALL JOINTS); costo-sternal syndrome (+MD-NEURAL or +MD-MUSCLE); chronic polyarthritis from autoimmune disease such as systemic lupus erythematosus (+MD-NEURAL where nerve pain dominates, +MD-MUSCLE where muscle pain dominates); breakbone (dengue) fever (+MD-NEURAL or +MD-MUSCLE depending on the dominant pain type); joint pain from viral or protozoal disease (+the matching regional device); joint pain from cancer, including chronic leukaemia or multiple myeloma (+the matching regional device); arthritis of the fingers at local painful points; rhizoarthrosis of the thumb (Forestier disease); carpal-tunnel syndrome; De Quervain disease.
MD-TISSUE
Collagen + Ascorbic Acid + Magnesium Gluconate + Pyridoxine Hydrochloride + Riboflavin + Thiamine Hydrochloride
Intended use: help movement by counteracting the physiological ageing of connective tissue, via a barrier effect, lubricating action, and mechanical support during other pharmacological treatment. Also used to limit the physiological deterioration of skin and subcutaneous connective tissue and counterbalance the effects of chrono-ageing and photo-ageing: local anti-ageing treatment, face and neck wrinkles, firming of the subcutaneous and perivascular connective layer of the face and neck, and altered connective tissue trophicity caused by airborne pollutants or metabolic disorders.
Directions: 2 treatments weekly for the first 2 weeks, then 1 weekly until improvement (average 8–10 sessions); may continue at 1 treatment every other week for up to 10 weeks in total. Chronic presentations — 1 treatment weekly for 1 month until improvement, then monthly. Three techniques are used depending on presentation: intradermal microinjections (1–3mm depth, 0.2–0.3ml into the affected tissue); the tunnelling technique for wrinkles (0.3ml per wrinkle); and periarticular injection (2–4mm depth, microinjections of 0.3–0.5ml).
Combinations: for face and neck wrinkles and subcutaneous connective tissue firming, GUNA recommends pairing with MD-MATRIX — typically 2 vials of MD-TISSUE to 1 vial of MD-MATRIX per treatment. Also indicated for patients who need general collagen supplementation or a topical anti-ageing treatment.
Featured products
Guna MD Tissue
Counteracts physiological ageing of connective tissue; barrier, lubricating, mechanical support.
Guna MD Matrix
Strengthens the extracellular matrix; defensive barrier against free radicals.
Explore the full Guna range — Collagen Medical Devices and other GUNA-Method products.
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Related reading
- Guna Collagen Medical Devices: What They Are and How They Work
- Guna Collagen Medical Devices: Anatomical Injection Atlas for Practitioners
Source: GUNA, *Collagen Medical Devices* reference catalogue.
Tags: Deep Guna Research, Guna Articles, Collagen Medical Devices, MD Devices